12.4. Laboratory Validation

The final validation of a diagnostic method is through inter-laboratory proficiency tests, to evaluate the reproducibility and the overall uncertainty of the method, and to assess performance of other laboratories to conduct specifically this method (Birch et al., 2004; Valentine-Thon et al., 2001; Verkooyen et al., 2003). To achieve this, candidate laboratories must submit to a training and accreditation programme.