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HomeArticlesAntiproliferative activity & apoptotic effects of Filipendula ulmaria against C26 colon tumour...

Antiproliferative activity & apoptotic effects of Filipendula ulmaria against C26 colon tumour cells

Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen’s antioxidant, anti-ageing, anti-inflammatory, anti-atherosclerosis, and cardioprotective activity, depending on the floral origin, are well known. Recent studies proposed that pollen may also be an excellent cancer-fighting candidate, as pollen harbours high amounts of phenolic substances. In our study, Filipendula ulmaria pollen (bee collected) was methanol-water extracted and used to verify its in vitro pharmacological activities on C26 mice cancer tumour cells. Three different concentrations of the extract were tested in antitumour assays. Monitoring was done after 6, 12, 24, and 48 hours. Promising results were obtained for antiproliferative and apoptotic activity of the pollen extracts, with high efficiency for the highest concentration (1 mg/mL). For both activities, time and concentration-dependent effects were observed. Pollen extracts or bee collected pollen has a high potential as an antitumour agent for use in human medicine, because they are both rich in bioactive compounds.

Mărgăoan R, Zăhan M, Mărghitaş LA, Dezmirean DS, Erler S, Bobiş O (2016) Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells. Journal of Apicultural Science, 60(1): 135-144. DOI: 10.1515/JAS-2016-0014

http://www.degruyter.com/view/j/jas.2016.60.issue-1/jas-2016-0014/jas-2016-0014.xml
COLOSS Association
COLOSS Associationhttps://coloss.org/
COLOSS (Prevention of honey bee COlony LOSSes) is an international, non-profit association headquartered in Bern, Switzerland that is focussed on improving the well-being of bees at a global level. We are composed of scientific professionals that include researchers, veterinarians, agriculture extension specialists and students. We understand that cooperation and open dialogue are key to better understanding the reasons why bee populations are threatened in today’s world.